Evolution and Quantitative Comparison of Genome-Wide Protein Domain Distributions
نویسندگان
چکیده
منابع مشابه
Evolution and Quantitative Comparison of Genome-Wide Protein Domain Distributions
The metabolic and regulatory capabilities of an organism are implicit in its protein content. This is often hard to estimate, however, due to ascertainment biases inherent in the available genome annotations. Its complement of recognizable functional protein domains and their combinations convey essentially the same information and at the same time are much more readily accessible, although pro...
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Investigations into the origins and evolution of regulatory mechanisms require quantitative estimates of the abundance and co-occurrence of functional protein domains among distantly related genomes. Currently available databases, such as the SUPERFAMILY, are not designed for quantitative comparisons since they are built upon transcript and protein annotations provided by the various different ...
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DNA methylation is a key component of mammalian gene regulation and the most classical example of an epigenetic mark. DNA methylation patterns are mitotically heritable and stable over time, but they undergo considerable changes in response to cell differentiation, diseases and environmental influences. Several methods have been developed for DNA methylation profiling on a genomic scale. Here, ...
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ژورنال
عنوان ژورنال: Genes
سال: 2011
ISSN: 2073-4425
DOI: 10.3390/genes2040912